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Depo-Testosterone Cypionate Androgen Shots are a long-acting esterized form of testosterone that is the longest form of steroid injection used in testosterone replacement. For this reason the dosing schedule is not as frequent as other methods of androgen administration like gels, creams or patches. Because the half life is longer, it requires less shots be taken to maintain a steady release of androgen into the blood stream. Results from cypionate therapy is very similar to that of enanthate testosterone injections treatment regimens and each has it benefits for successfully replacing lost or low androgen levels in men.

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Depo-Testosterone Cypionate is a very long-acting injectable steroid hormone. While cypionates like Depo-Testosterone are the most popular form of TRT, both of these esterized androgen steroid injections are very effective for use in testosterone therapy and men get excellent results from either one. The main difference is the half life or amount of time the steroid hormone remains circulating in the body. Cypionate is a longer acting testosterone than enanthate and so the dosing schedule is less frequent. Some men like the results they get from enanthate vs cypionate and others have only tried the cypionate form of therapy and can't compare the treatment results. Your physician can help guide you by explaining the similarities and difference between the two drugs to help you make the best decision for your specific treatment plan. AVEED® is a new testosterone therapy option that has a very infrequent dosing schedule - learn more about Aveed® Testosterone Therapy Injections.

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Using HCG with Testosterone at the same tome. Use the auxiliary drugs as prescribed. HCG Injections (Human Chorionic Gonaditropin) should be taken daily to avoid testicular atrophy. Do not skip taking the estrogen blockers or estrogen inhibitors as they are instrumental in preventing excessive aromatization of testosterone to estrogen. Read more about using testosterone with HCG Injections online - HCG Injections for Sale.

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  • Depo-Testosterone 100 mg per mL (10 mL vials) - 10 mL vial NDC 0781-3073-70
  • Depo-Testosterone 200 mg per mL (1 or 10 mL vials) - 1 mL vial NDC 0781-3074-71; 10 mL vial NDC 0781-3074-70
  • Product Ingredients: Testosterone cypionate, Benzyl benzoate, Cottonseed oil, Benzyl alcohol (as preservative)

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Pfizer's Depo-Testosterone comes in 2 Dosages 100mg/mL and 200mg /mL

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Drug Description: Depo-Testosterone (testosterone cypionate injection, USP CIII). DEPO-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil -soluble 17 (beta) - cyclopenty lpropionate ester of the androgenic hormone testosterone. Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearlyso and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. The chemical name for testosterone cypionate is androst-4-en-3-one, 17-(3-cyclopentyl-1-oxopropoxy)-, (17ß)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

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Pfizer's DEPO-Testosterone Injection is available in two strengths, 100 mg/mL and 200 mg/mL testosterone cypionate.

Each mL of the 100 mg/mL solution contains: Testosterone cy pionate..... 100 mg Benzy l benzoate ..... 0.1 mL Cottonseed oil .... l alcohol (as pres ervative) ..... 9.45 mg

Each mL of the 200 mg/mL solution contains: Testosterone cy pionate .... 200 mg Benzy l benzoate .... 0.2 mL Cottonseed oil .... 560 mg Benzy l alcohol (as preservative) .... 9.45 mg

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    DEPO-Testosterone Injection, for intramuscular injection, contains testosterone cypionate which is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone.

    Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils such as sesame, cottonseed and grapeseed oil.

    The chemical name for testosterone cypionate is androst-4-en-3-one, 17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.

    The structural formula of Depo-Testosterone is represented below:

    Depo® Testosterone (testosterone cypionate) Structural Formula

    DEPO-Testosterone Injection is available in two strengths, 100 mg/mL and 200 mg/mL testosterone cypionate.

    Each mL of the 100 mg/mL solution contains:

    Testosterone cypionate.................100 mg
    Benzyl benzoate.................0.1 mL
    Cottonseed oil.................736 mg
    Benzyl alcohol (as preservative).................9.45 mg

    Each mL of the 200 mg/mL solution contains:

    Testosterone cypionate.................200 mg
    Benzyl benzoate.................0.2 mL
    Cottonseed oil.................560 mg
    Benzyl alcohol (as preservative).................9.45 mg

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    Testosterone is a naturally occurring sex hormone that is produced in a man's testicles. Small amounts of testosterone are also produced in a woman's ovaries and adrenal system.

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    Get medical help if you have any of these signs or an allergic reaction to Depo-Testosterone Injections: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your treating physician if you have any of these serious side effects: swelling, rapid weight gain; increased or ongoing erection of the penis; bone pain, increased thirst, memory problems, restless feeling, confusion, nausea, loss of appetite, increased urination, weakness, muscle twitching; or nausea, vomiting, stomach pain, loss of appetite, and jaundice yellowing of the skin or eyes.

    Women receiving testosterone injection may develop male characteristics, which could be irreversible if testosterone treatment is continued. Call your HRT doctor as soon as possible if you notice any of these signs of excess testosterone: acne; changes in your menstrual periods; male-pattern hair growth such as on the arms, chin or chest; male pattern baldness; enlarged clitoris; or increase or decrease in sex drive. Less serious side effects may include: aromatization, gynecomastea or breast swelling in men; headache, anxiety, depressed mood; numbness or tingly feeling; or pain or swelling where the medicine was injected.


    Before receiving testosterone injection, tell your doctor if you have benign prostatic hypertrophy (BPH), a bleeding or blood clotting disorder, high cholesterol, any type of cancer, liver or kidney disease, or heart disease, coronary artery disease, or a history of cardivascular disease or heart attack. You should not receive this medication if you have: prostate cancer; male breast cancer; if you are pregnant; or if you have ever had an allergic reaction to a hormone treatment.

    Before taking testosterone injection, tell your doctor if you are allergic to any drugs, or if you have: benign prostatic hypertrophy (BPH); any type of cancer; high cholesterol; a bleeding or blood clotting disorder; liver or kidney disease; or heart disease, coronary artery disease (hardened arteries), congestive heart failure, or a history of heart attack. If you have any of these conditions, you may need a dose adjustment or special tests to safely use testosterone injection.


    Testosterone injection is given as an shot into a muscle of your buttocks. Most Hormone Replacment Therapy patients self-administer theie homone drugs such as testosterone, HCG, HGH (Somatropin), ED penile injections TriMix, Caverject, and Sermorelin. Your doctor, nurse, or other healthcare provider can also give you this injection. Testosterone injections are usually taken every 2 to 4 weeks.

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    The number of months you need to use testosterone injection before you see results will depend on the condition being treated. To be sure this steroid injections medication is helping your condition, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your Low T Doctor.

    Indications & Depo-Testosterone Dosage


    DEPO-Testosterone Injection is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.

    1. Primary hypogonadism - congenital or acquired testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
    2. Secondary - Hypogonadotropic hypogonadism congenital or acquired gonadotropin deificiency or LHRH deficiency, or pituitary hypothalamic injury from tumors, trauma, or radiation.

    Safety and efficacy of DEPO-Testosterone (testosterone cypionate) in men with “age-related hypogonadism” also referred to as “late-onset hypogonadism” have not been established.


    Prior to initiating DEPO-Testosterone testosterone cypionate, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range.

    DEPO-Testosterone Injection is for intramuscular use only.

    It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle.

    The suggested dosage for DEPO-Testosterone Injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions.

    Various testosteone steroid dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.

    For replacement in the hypogonadal male, 50mg – 400 mg should be administered every two to four weeks.

    Prescription testosterone drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.


    DEPO-Testosterone Injection is available as follows:

    100 mg/mL

    10 mL vials NDC 0009-0347-02

    200 mg/mL

    1 mL vials NDC 0009-0417-01
    10 mL vials NDC 0009-0417-02

    Vials should be stored at controlled room temperature 20° to 25°C (68° to 77°F), USP. Protect from light.

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